CDKN2A - cyclin dependent kinase inhibitor 2A. Sinónimo(s) : ARF, CDK4I, CMM2, INK4, INK4a, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf; Símbolos e

CDKN2A gene deletion is associated with an adverse prognosis in pediatric, adolescent, and adult patients with B-cell ALL (B-cell precursor or BCP-ALL) due to increased risk for relapse, poor response to therapy, lower overall survival, and/or higher incidence of concurrent deletion of other genes.

The gene codes for two proteins, both acting as tumor suppressors. Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2a is the second most commonly inactivated gene in cancerous tissues after p53. This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progre 2016-06-01 · A germline hemizygous loss of CDKN2A associated with lower endogenous p14 ARF suggests possible p14 ARF haploinsufficiency, which may affect p53-dependent cell cycle control even in the absence of Kaplan-Meier analysis showed that increased CDKN2A expression was associated with increased survival time in breast cancer patients (P=0.000), especially in Luminal-like subtype. Univariate and multivariate Cox analyses indicated that CDKN2A expression was an independent prognostic biomarker for breast cancer (P=0.037). 2020-10-16 · CDKN2A/p16INK4a Antibody (F-12) is a monoclonal anti-p16 INK4A antibody that is recommended for WB, IP, IF, IHC(P) and ELISA. Cited in 433 publications XL CDKN2A consists of an orange-labeled probe hybridizing to the CDKN2A (p16)/CDKN2B (p15) gene region at 9p21 and a green-labeled probe hybridizing to the centromere of chromosome 9.

Cdkn2a

However, CDKN2A mutations are rarely found in uveal melanoma patients; Melanoma, cutaneous malignant 2 (CMM2) [MIM:155601]: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. 2016-10-05 Rabbit monoclonal [EPR17878] to CDKN2A/p14ARF - BSA and Azide free. Application: Flow Cyt, ICC/IF, IP, WB. Reactivity: Human. Conjugate: Unconjugated. Recombinant. Anti-CDKN2A/p14ARF antibody [SP271] - BSA and Azide free (ab271999) Description: Rabbit monoclonal [SP271] to CDKN2A/p14ARF - BSA and Azide free.

CDKN2A has 10,679 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, … 2020-11-20 It has been reported that CDKN2A and CDKN2B are frequently inactivated in various hematologic malignancies. 1,4 Loss of heterozygosity (LOH) of chromosome arm 9p, including the CDKN2A locus, is one of the most frequent genetic events in childhood acute lymphoblastic leukemia (ALL), suggesting inactivation of the second allele or, possibly, haploinsufficiency. 5-8 Haploinsufficiency of a tumor CDKN2A expression was correlated with an inferior rate of recurrent disease (p = 0.02).

2017-12-08 · CDKN2A, also known as cyclin-dependent kinase Inhibitor 2A, is a gene on chromosome 9. The gene codes for two proteins, both acting as tumor suppressors. Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2a is the second most commonly inactivated gene in cancerous tissues after p53.

Det innebär att dessa mutationer är pådrivande i den process som leder till att celler blir elakartade. CDKN2A signals were equally identifiable by AM-FISH and conventional FISH in normal mononuclear blood cells. In contrast, when two BCL cell lines lacking CDKN2A were analyzed, CDKN2A signals were not detected by AM-FISH, whereas conventional FISH yielded false signals. CDKN2A Q50fs results in a change in the amino acid sequence of the Cdkn2a protein beginning at aa 50 of 156, likely resulting in premature truncation of the functional protein (UniProt.org).

CDKN2A expression was correlated with an inferior rate of recurrent disease (p = 0.02). In high-risk HPV DNA+ vulvar squamous cell carcinomas patients with CDKN2A- carcinomas showed a significantly worse overall survival than women with CDKN2A+ tumors (56% vs.100%, p = 0.003).

It is ubiquitously expressed in many tissues and cell types. [6] The gene codes for two proteins , including the INK4 family member p16 (or p16INK4a) and p14arf . [7] Mutationer i CDKN2A-genen orsakar ökad risk hos bärare att drabbas av framförallt malignt melanom. Bärare kan även ha en ökad risk att drabbas av andra tumörsjukdomar tex pankreascancer. Upp till 19% av svenska familjer med hereditär belastning för att utveckla malignt melanom har mutation i CDKN2A-genen.

Functional Associations. CDKN2A has 10,679 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 86 datasets. CDKN2A expression was correlated with an inferior rate of recurrent disease (p = 0.02).
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The CDKN2B gene is adjacent to CDKN2A and encodes the p15 (INK4B) protein, which also binds to and inactivates CDK4/6. 2017-12-08 · CDKN2A, also known as cyclin-dependent kinase Inhibitor 2A, is a gene on chromosome 9. The gene codes for two proteins, both acting as tumor suppressors. Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2a is the second most commonly inactivated gene in cancerous tissues after p53.

This fluorescence in situ hybridization (FISH) probe is intended to detect deletion of the LSI CDKN2A (p16) probe target within the 9p21 chromosome region. Alterations of the 9p21 CDKN2A (ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf) protein expression summary. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies.
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Complete information for CDKN2A-DT gene (RNA Gene), CDKN2A Divergent Transcript, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The …

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